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A functional genetic link between distinct developmental language disorders.

Abstract:

BACKGROUND: Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment. METHODS: We performed genomic screening for regions bound by FOXP2 using chromatin immunoprecipitation, which led us to focus on one particular gene that was a strong candidate for involvement in language impairments. We then tested for associations be...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa0802828

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Journal:
New England journal of medicine
Volume:
359
Issue:
22
Pages:
2337-2345
Publication date:
2008-11-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
34471

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