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A functional genetic link between distinct developmental language disorders.

Abstract:

BACKGROUND: Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment. METHODS: We performed genomic screening for regions bound by FOXP2 using chromatin immunoprecipitation, which led us to focus on one particular gene that was a strong candidate for involvement in language impairments. We then tested for associations be...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa0802828

Authors


Vernes, SC More by this author
Newbury, DF More by this author
Abrahams, BS More by this author
Winchester, L More by this author
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Journal:
The New England journal of medicine
Volume:
359
Issue:
22
Pages:
2337-2345
Publication date:
2008-11-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:63957647-9429-413e-8652-9124f3d86ff4
Source identifiers:
34471
Local pid:
pubs:34471

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