Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.

Journal article

In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene (Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an approximately 30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in c...

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Authors: Olsson, A; Lilja, H; Lundwall, A

• Journal: Genomics
• Volume: 84
• Issue: 1
• Pages: 147-156
• Publication date: 2004-07-01
• DOI: 10.1016/j.ygeno.2004.01.009
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: Evolution, Molecular; Rats; Phylogeny; Humans; Gene Dosage; Gene Expression Regulation, Neoplastic; Prostatic Neoplasms; Classification; Adenocarcinoma; Animals; Male; Base Sequence; Molecular Sequence Data; Kallikreins; Prostate-Specific Antigen; Mice