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Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.

Abstract:

In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene (Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an approximately 30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in c...

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Publisher copy:
10.1016/j.ygeno.2004.01.009

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Genomics More from this journal
Volume:
84
Issue:
1
Pages:
147-156
Publication date:
2004-07-01
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
Language:
English
Keywords:
Pubs id:
pubs:365987
UUID:
uuid:63946761-b39d-445e-81fc-15e841956f6a
Local pid:
pubs:365987
Source identifiers:
365987
Deposit date:
2013-11-16

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