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Thesis

The role of chemerin and chemerin receptors during acute inflammation

Abstract:

Cytokines play a major role in orchestrating the inflammatory process. This thesis focuses on one such cytokine, called chemerin. Chemerin is a multifunctional protein that is secreted as an inactive precursor, prochemerin, which becomes proteolytically cleaved at the C-terminus into the active signalling molecule, chemerin. Chemerin binds three G-protein coupled receptors: ChemR23, GPR1 and CCRL2, and acts as a chemoattractant, primarily via the ChemR23 receptor expressed on immature dend...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:638a68e6-fef5-4a84-8c5d-4acd702b8aa7
Deposit date:
2018-01-04

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