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Journal article

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

Abstract:

p56lck, a member of the src family of protein tyrosine kinases, is an essential component in T cell receptor (TCR) signal transduction. p56lck contains a src homology 2 (SH2) domain found in a number of proteins involved in intracellular signaling. SH2 domains have been implicated in protein-protein interactions by binding to sequences in target proteins containing phosphorylated tyrosine. Using an in vitro assay, we have studied specific binding of tyrosine-phosphorylated proteins to a recom...

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Publication status:
Published

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Publisher copy:
10.1084/jem.179.4.1163

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of experimental medicine More from this journal
Volume:
179
Issue:
4
Pages:
1163-1172
Publication date:
1994-04-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:15879
UUID:
uuid:638584fa-eae3-4465-a398-8bf7c27290fe
Local pid:
pubs:15879
Source identifiers:
15879
Deposit date:
2012-12-19

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