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Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS.

Abstract:

HIV-1 infects dendritic cells (DCs) without triggering an effective innate antiviral immune response. As a consequence, the induction of adaptive immune responses controlling virus spread is limited. In a recent issue of Immunity, Lahaye and colleagues show that intricate interactions of HIV capsid with the cellular cofactor cyclophilin A (CypA) control infection and innate immune activation in DCs. Manipulation of HIV-1 capsid to increase its affinity for CypA results in reduced virus infect...

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Publication status:
Published

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Publisher copy:
10.1002/bies.201400019

Authors


Journal:
BioEssays : news and reviews in molecular, cellular and developmental biology
Volume:
36
Issue:
7
Pages:
649-657
Publication date:
2014-07-05
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
URN:
uuid:63847053-d530-49da-a2c8-c178fd784d72
Source identifiers:
463114
Local pid:
pubs:463114

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