Safety and efficacy of aneurysm treatment with the WEB: Results of the WEBCAST 2 Study

Pierot, L; Gubucz, I; Buhk, J; Holtmannspötter, M; Herbreteau, D; Stockx, L; Spelle, L; Berkefeld, J; Januel, A; Molyneux, A; Byrne, J; Fiehler, J; Szikora, I; Barreau, X

Journal article

Safety and efficacy of aneurysm treatment with the WEB: Results of the WEBCAST 2 Study

Abstract:: BACKGROUND AND PURPOSE:Flow disruption with the Woven EndoBridge (WEB) device is an innovative technique for the endovascular treatment of wide-neck bifurcation aneurysms. The initial version of the device (WEB Double-Layer) was evaluated in the WEB Clinical Assessment of IntraSaccular Aneurysm Therapy (WEBCAST) study, whereas the French Observatory study evaluated both WEB Double-Layer and Single-Layer versions of the device. WEBCAST 2 was designed to evaluate the WEB Single-Layer with Enhanced Visualization. MATERIALS AND METHODS:Patients with wide-neck bifurcation aneurysms for which WEB treatment was possible were included. Clinical data including adverse events and clinical status at 1 month and 1 year were collected and analyzed. A core laboratory evaluated anatomic results at 1 year following the procedure. RESULTS:Ten European neurointerventional centers included 55 patients (38 women; 27-77 years of age; mean, 54.4 ± 10.0 years) with 55 aneurysms. Aneurysm locations were the middle cerebral artery in 25 aneurysms (45.5%), the anterior communicating artery in 16 (29.1%), the basilar artery in 9 (16.4%), and the internal carotid artery terminus in 5 (9.1%). Procedural morbidity and mortality at 1 month were, respectively, 1.8% (1/55 patients) and 0.0% (0/55 patients). Morbidity and mortality at 1 year were, respectively, 3.9% (2/51 patients) and 2.0% (1/51 patients). At 1 year, complete occlusion was observed in 27/50 aneurysms (54.0%); neck remnant, in 13/50 (26.0%); and aneurysm remnant, in 10/50 (20.0%) (adequate occlusion in 40/50, 80.0%). CONCLUSIONS:WEBCAST 2 confirms the high safety and efficacy of WEB aneurysm treatment demonstrated in the WEBCAST and French Observatory studies.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Pierot, L., Gubucz, I., Buhk, J., Holtmannspötter, M., Herbreteau, D., Stockx, L., Spelle, L., Berkefeld, J., Januel, A., Molyneux, A., Byrne, J., Fiehler, J., Szikora, I., & Barreau, X. (2017). Safety and efficacy of aneurysm treatment with the WEB: Results of the WEBCAST 2 Study. American Journal of Neuroradiology, 38(6), 1151–1155.

MLA Style

Pierot, L., et al. “Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study.” American Journal of Neuroradiology, vol. 38, no. 6, American Society of Neuroradiology, 2017, pp. 1151–55.

Chicago Style

Pierot, L, I Gubucz, J Buhk, M Holtmannspötter, D Herbreteau, L Stockx, L Spelle, et al. 2017. “Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study.” American Journal of Neuroradiology 38 (6): 1151–55.
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