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Journal article

L‐arginine promotes gut hormone release and reduces food intake in rodents

Abstract:

Aims: To investigate the anorectic effect of L‐arginine (L‐Arg) in rodents. Methods: We investigated the effects of L‐Arg on food intake, and the role of the anorectic gut hormones glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY), the G‐protein‐coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents. Results: Oral gavage of L‐Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet‐induced obese mice...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/dom.12644

Authors


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BB/I001816/1/Biotechnology and Biological Sciences Research Council More from this funder
/Biotechnology and Biological Sciences Research Council More from this funder
/Medical Research Council More from this funder
NC/K500379/1/National Centre for the Replacement, Refinement and Reduction of Animals in Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
Diabetes, Obesity and Metabolism Journal website
Volume:
18
Issue:
5
Pages:
508-518
Publication date:
2016-04-01
Acceptance date:
2016-02-07
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
Pmid:
26863991
Source identifiers:
606151

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