- Abstract:
-
Aims: To investigate the anorectic effect of L‐arginine (L‐Arg) in rodents. Methods: We investigated the effects of L‐Arg on food intake, and the role of the anorectic gut hormones glucagon‐like peptide‐1 (GLP‐1) and peptide YY (PYY), the G‐protein‐coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents. Results: Oral gavage of L‐Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet‐induced obese mice...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 928.6KB)
-
- Publisher copy:
- 10.1111/dom.12644
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- Diabetes, Obesity and Metabolism Journal website
- Volume:
- 18
- Issue:
- 5
- Pages:
- 508-518
- Publication date:
- 2016-04-01
- Acceptance date:
- 2016-02-07
- DOI:
- EISSN:
-
1463-1326
- ISSN:
-
1462-8902
- Pubs id:
-
pubs:606151
- URN:
-
uri:6381674f-80d6-41c9-b55c-cbc00b28b5ac
- UUID:
-
uuid:6381674f-80d6-41c9-b55c-cbc00b28b5ac
- Local pid:
- pubs:606151
- Language:
- English
- Keywords:
- Copyright holder:
- Alamshah et al.
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. Diabetes, Obesity and Metabolism published by John Wiley and Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
L‐arginine promotes gut hormone release and reduces food intake in rodents
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Funding
BB/I001816/1/Biotechnology and Biological Sciences Research Council
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/Medical Research Council
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/Biotechnology and Biological Sciences Research Council
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NC/K500379/1/National Centre for the Replacement, Refinement and Reduction of Animals in Research
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