Journal article
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
- Abstract:
-
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respect...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1074-7613(00)80007-2
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Bibliographic Details
- Journal:
- Immunity
- Volume:
- 10
- Issue:
- 1
- Pages:
- 63-74
- Publication date:
- 1999-01-01
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- Source identifiers:
-
20601
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:20601
- UUID:
-
uuid:63772fc9-65f4-4bab-a90b-4b9a34ff5a1f
- Local pid:
- pubs:20601
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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