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Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.

Abstract:

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respect...

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Publication status:
Published

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Journal:
Immunity
Volume:
10
Issue:
1
Pages:
63-74
Publication date:
1999-01-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
20601

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