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Journal article

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.

Abstract:

Plasmodium falciparumantigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their identification has proven elusive. Here we report the isolation of human monoclonal antibodies that recognize ery...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature16450

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Swiss Vaccine Research Institute More from this funder
Helmut Horten Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
529
Issue:
7584
Pages:
105-109
Publication date:
2015-12-23
Acceptance date:
2015-11-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
588858

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