Journal article
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
- Abstract:
-
Plasmodium falciparumantigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their identification has proven elusive. Here we report the isolation of human monoclonal antibodies that recognize ery...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/nature16450
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Authors
Funding
Swiss Vaccine Research Institute
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Helmut Horten Foundation
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 529
- Issue:
- 7584
- Pages:
- 105-109
- Publication date:
- 2015-12-23
- Acceptance date:
- 2015-11-16
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Source identifiers:
-
588858
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:588858
- UUID:
-
uuid:6375b9e4-0d1a-4813-9c20-aac016a0ec07
- Local pid:
- pubs:588858
- Deposit date:
- 2016-04-06
Terms of use
- Copyright date:
- 2015
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