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Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles

Abstract:

Parkinson's disease (PD) is a progressive and currently incurable neurological disorder characterised by the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (a-syn). Oligomeric a-syn is proposed to play a central role in spreading protein aggregation in the brain with associated cellular toxicity contributing to a progressive neurological decline. For this reason, a-syn oligomers have attracted interest as therapeutic targets for neurodegenerative cond...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0181844

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
El-Turabi, A
Grant:
Synuclein Therapeutic Acceleration Program (SynTAP 2013) grant 8344
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Funding agency for:
Hunn, B
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Funding agency for:
Wade-Martins, R
Grant:
Synuclein Therapeutic Acceleration Program (SynTAP 2013) grant 8344
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
8
Article number:
e0181844
Publication date:
2017-08-10
Acceptance date:
2017-07-08
DOI:
ISSN:
1932-6203
Pmid:
28797124
Source identifiers:
723869
Language:
English
Pubs id:
pubs:723869
UUID:
uuid:6372ea3a-be1e-40ca-9cfd-71ad1a24621f
Local pid:
pubs:723869
Deposit date:
2017-09-07

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