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Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles

Abstract:

Parkinson's disease (PD) is a progressive and currently incurable neurological disorder characterised by the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (a-syn). Oligomeric a-syn is proposed to play a central role in spreading protein aggregation in the brain with associated cellular toxicity contributing to a progressive neurological decline. For this reason, a-syn oligomers have attracted interest as therapeutic targets for neurodegenerative cond...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
Swiss National Science Foundation
Funding agency for:
Bachmann, M
Grant:
31003A_149925
More from this funder
Name:
Michael J Fox Foundation
Funding agency for:
El-Turabi, A
Wade-Martins, R
Bachmann, M
Grant:
Synuclein Therapeutic Acceleration Program (SynTAP 2013) grant 8344
Synuclein Therapeutic Acceleration Program (SynTAP 2013) grant 8344
31003A_149925
More from this funder
Name:
Guarantors of Brain
Funding agency for:
Hunn, B
More from this funder
Name:
Goodger and Schorstein Scholarship
Funding agency for:
Hunn, B
More from this funder
Name:
Rhodes Trust
Funding agency for:
Hunn, B
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
12
Issue:
8
Article number:
e0181844
Publication date:
2017-08-10
Acceptance date:
2017-07-08
DOI:
ISSN:
1932-6203
Pmid:
28797124
Language:
English
Pubs id:
pubs:723869
UUID:
uuid:6372ea3a-be1e-40ca-9cfd-71ad1a24621f
Local pid:
pubs:723869
Source identifiers:
723869
Deposit date:
2017-09-07

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