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DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase.

Abstract:

Pso2/Snm1 is a member of the beta-CASP metallo-beta-lactamase family of proteins that include the V(D)J recombination factor Artemis. Saccharomyces cerevisiae pso2 mutants are specifically sensitive to agents that induce DNA interstrand cross-links (ICLs). Here we establish a novel overlapping function for PSO2 with MutS mismatch repair factors and the 5'-3' exonuclease Exo1 in the repair of DNA ICLs, which is confined to S phase. Our data demonstrate a requirement for NER and Pso2, or Exo1 a...

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Publication status:
Published

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Journal:
Molecular and cellular biology More from this journal
Volume:
25
Issue:
6
Pages:
2297-2309
Publication date:
2005-03-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
Language:
English
Keywords:
Pubs id:
pubs:178254
UUID:
uuid:6371b6bd-4a82-4103-a806-0199145b8e16
Local pid:
pubs:178254
Source identifiers:
178254
Deposit date:
2013-11-16

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