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An investigation of the role of auditory cortex in sound localization using muscimol-releasing Elvax.

Abstract:

Lesion studies suggest that primary auditory cortex (A1) is required for accurate sound localization by carnivores and primates. In order to elucidate further its role in spatial hearing, we examined the behavioural consequences of reversibly inactivating ferret A1 over long periods, using Elvax implants releasing the GABA(A) receptor agonist muscimol. Sub-dural polymer placements were shown to deliver relatively constant levels of muscimol to underlying cortex for >5 months. The measured ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
The European journal of neuroscience
Volume:
19
Issue:
11
Pages:
3059-3072
Publication date:
2004-06-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:636d7648-7871-4abb-bb31-efc5d9e80c51
Source identifiers:
114635
Local pid:
pubs:114635

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