- Abstract:
-
DNA polymerase eta (pol η) is the only DNA polymerase causally linked to carcinogenesis in humans. Inherited deficiency of pol η in the variant form of xeroderma pigmentosum (XPV) predisposes to UV-light-induced skin cancer. Pol η-deficient cells demonstrate increased sensitivity to cisplatin and oxaliplatin chemotherapy. We have found that XP30R0 fibroblasts derived from a patient with XPV are more resistant to cell kill by ionising radiation (IR) than the same cells complemented with wild-t...
Expand abstract - Publication status:
- Published
- Files:
-
-
(pdf, 1.8mb)
-
- Publisher copy:
- 10.1093/carcin/bgs239
-
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- Journal:
- Carcinogenesis
- Volume:
- 33
- Issue:
- 11
- Pages:
- 2026-2034
- Publication date:
- 2012-11-05
- DOI:
- EISSN:
-
1460-2180
- ISSN:
-
0143-3334
- URN:
-
uuid:636c696c-33b8-4402-a165-a46f3b3c957e
- Source identifiers:
-
350545
- Local pid:
- pubs:350545
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
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