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Journal article

PARK2 mutation causes metabolic disturbances and impaired survival of human iPSC-derived neurons

Abstract:

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson's disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and without PARK2 knockout (KO). The proteomic analysis quantified nearly 60% of all mitochondrial proteins...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Frontiers Media
Journal:
Frontiers in Cellular Neuroscience More from this journal
Volume:
13
Pages:
297
Publication date:
2019-07-05
Acceptance date:
2019-06-18
DOI:
EISSN:
1662-5102
Pmid:
31333417
Language:
English
Keywords:
Pubs id:
pubs:1033194
UUID:
uuid:636c5167-67db-4d36-bf66-54908443e72b
Local pid:
pubs:1033194
Source identifiers:
1033194
Deposit date:
2019-09-10

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