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Journal article

Living on the edge with too many mouths to feed: why dopamine neurons die.

Abstract:

Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architect...

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Publication status:
Published

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Publisher copy:
10.1002/mds.25135

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Movement disorders : official journal of the Movement Disorder Society
Volume:
27
Issue:
12
Pages:
1478-1483
Publication date:
2012-10-05
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
URN:
uuid:636a040d-3c78-4be9-94b6-768219acab52
Source identifiers:
375287
Local pid:
pubs:375287

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