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Journal article

Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore

Abstract:

Amyloid fibrillation is a nucleation-dependent process known be involved in the development of more than 20 progressive and chronic diseases. The detection of amyloid formation at the nucleation stage can greatly advance early diagnoses and treatment of diseases. In this work, we developed a new assay for the early detection of amylin fibrillation using the biarsenical dye 4,5-bis(1,3,2-dithiarsolan-2-yl)fluorescein (FlAsH), which could recognise tetracysteine...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.talanta.2017.05.015

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
Publisher:
Elsevier
Journal:
Talanta More from this journal
Volume:
173
Pages:
44-50
Publication date:
2017-05-17
Acceptance date:
2017-05-08
DOI:
EISSN:
1873-3573
ISSN:
0039-9140
Language:
English
Keywords:
Pubs id:
pubs:994719
UUID:
uuid:6363ac44-5405-4a5e-886a-e12e93becc6a
Local pid:
pubs:994719
Source identifiers:
994719
Deposit date:
2019-07-04

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