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The repopulation capacity of bone marrow grafts following pretreatment with monoclonal antibodies against T lymphocytes in rhesus monkeys.

Abstract:

Complement-mediated lysis of (subsets of) T lymphocytes in bone marrow grafts is increasingly used to prevent acute graft-versus-host disease in human bone marrow transplant recipients, especially in case of major immunogenetic disparity between donor and recipient. Since T lymphocyte depletion has resulted in an increased frequency of allogeneic engraftment failures, its effect on hemopoietic reconstitution was measured in rhesus monkeys. The reactivity patterns of commonly used types of ant...

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Publication status:
Published

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Journal:
Transplantation
Volume:
45
Issue:
2
Pages:
301-307
Publication date:
1988-02-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:635ca67a-6a43-4b79-b496-7549080aa475
Source identifiers:
1976
Local pid:
pubs:1976

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