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Vstx1, a modifier of Kv channel gating, localizes to the interfacial region of lipid bilayers.

Abstract:

VSTx1 is a tarantula venom toxin which binds to the archaebacterial voltage-gated potassium channel KvAP. VSTx1 is thought to access the voltage sensor domain of the channel via the lipid bilayer phase. In order to understand its mode of action and implications for the mechanism of channel activation, it is important to characterize the interactions of VSTx1 with lipid bilayers. Molecular dynamics (MD) simulations (for a total simulation time in excess of 0.2 micros) have been used to explore...

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Publication status:
Published

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Publisher copy:
10.1021/bi061111z

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Journal:
Biochemistry
Volume:
45
Issue:
39
Pages:
11844-11855
Publication date:
2006-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:635c0b4b-bc4c-4ae7-9c21-7103262f9568
Source identifiers:
100495
Local pid:
pubs:100495

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