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Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells

Abstract:

Myeloid-derived suppressor cells (MDSCs) are key players in immune evasion, tumor progression and metastasis. MDSCs accumulate under various pathological states and fall into two functionally and phenotypically distinct subsets that have been identified in humans and mice: polymorphonuclear (PMN)-MDSCs and monocytic (M)-MDSCs. As dogs are an excellent model for human tumor development and progression, we set out to identify PMN-MDSCs and M-MDSCs in clinical canine oncology patients. Canine hy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-9357-944X
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Name:
NIH HHS
Grant:
T35 OD010919
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Name:
Wellcome Trust
Grant:
203141/Z/16/Z
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Name:
Wellcome Trust (Wellcome)
Grant:
203141/Z/16/Z
Publisher:
Nature Research
Journal:
Scientific Reports More from this journal
Volume:
9
Issue:
2019
Article number:
3574
Publication date:
2019-03-05
Acceptance date:
2019-02-13
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
30837603
Language:
English
Keywords:
Pubs id:
pubs:980549
UUID:
uuid:635879bb-eef3-4d4b-9fcf-ed2779781d44
Local pid:
pubs:980549
Source identifiers:
980549
Deposit date:
2019-04-04

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