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Inhibition of group B streptococcal growth by IFN gamma-activated human glioblastoma cells.

Abstract:

Group B streptococci are the most important bacteria inducing neonatal septicemia and meningitis. The aim of this study was to assess the role of IFNgamma in the induction of anti-microbial effector mechanisms in human brain tumor cells. Different human glioblastoma/astrocytoma cell lines, stimulated with IFNgamma, restricted the growth of group B streptococci. In addition, we found that TNF alpha is able to enhance the IFNgamma-mediated anti-microbial effect. In contrast to group B streptoco...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Journal of neuroimmunology
Volume:
89
Issue:
1-2
Pages:
191-197
Publication date:
1998-08-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:63543697-335f-4d3c-83b2-90e7ff50dc7f
Source identifiers:
131230
Local pid:
pubs:131230

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