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Journal article

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

Abstract:

The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a contributory role in type 2 diabetes susceptibility. Indeed, functional studies have implicated the G971R variant, and a recent meta-analysis of 27 association studies suggested that carriage of 971R was associated with a 25% increase in disease risk. However, this association has not been evaluated in large samples. The present study genotyped the P512A and G971R IRS1 variants in 971 U.K. typ...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.53.12.3319

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Diabetes More from this journal
Volume:
53
Issue:
12
Pages:
3319-3322
Publication date:
2004-12-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Language:
English
Keywords:
Pubs id:
pubs:23927
UUID:
uuid:63528411-90d8-4d13-9c33-31e1fb93b596
Local pid:
pubs:23927
Source identifiers:
23927
Deposit date:
2012-12-19

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