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Cohesin can remain associated with chromosomes during DNA replication

Abstract:

To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed of its Smc and kleisin (Scc1) subunits. How such structures are created during S phase is poorly understood, in particular whether they are derived from complexes that had entrapped DNAs prior to replication. To address this, we used selective photobleaching to determine...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2017.08.092

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-5853-7343
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Funding agency for:
Nasmyth, KA
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Funding agency for:
Nasmyth, KA
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
12
Pages:
2749-2755
Publication date:
2017-09-19
Acceptance date:
2017-08-28
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:731041
URN:
uri:634b5951-fe2c-4ea0-9475-be16aa88e6a2
UUID:
uuid:634b5951-fe2c-4ea0-9475-be16aa88e6a2
Local pid:
pubs:731041
Language:
English
Keywords:

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