Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study.

Journal article

Cytogenetic and molecular investigations of Acute Lymphoblastic Leukaemia (ALL) have identified the existence of distinct clinical subgroups. Molecular monitoring of clonal Immunoglobulin and T cell receptor (IG/TR) gene rearrangements has become an important tool in stratification of therapy of ALL. In order to determine whether certain features of the patient-specific rearrangements could hold further prognostic clues or provide information on the cell of origin of ALL, a comprehensive anal...

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Authors: Rai, L; Casanova, A; Moorman, A; Richards, S; Buck, G

• Publication status: Published
• Journal: British journal of haematology
• Volume: 148
• Issue: 3
• Pages: 394-401
• Publication date: 2010-02-01
• DOI: 10.1111/j.1365-2141.2009.07966.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Gene Rearrangement, T-Lymphocyte; Translocation, Genetic; Middle Aged; Receptors, Antigen, T-Cell; Immunophenotyping; Female; Male; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Adolescent; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Immunoglobulin Variable Region; Complementarity Determining Regions; Humans; Adult; Young Adult