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Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study.

Abstract:

Cytogenetic and molecular investigations of Acute Lymphoblastic Leukaemia (ALL) have identified the existence of distinct clinical subgroups. Molecular monitoring of clonal Immunoglobulin and T cell receptor (IG/TR) gene rearrangements has become an important tool in stratification of therapy of ALL. In order to determine whether certain features of the patient-specific rearrangements could hold further prognostic clues or provide information on the cell of origin of ALL, a comprehensive anal...

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Publication status:
Published

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Authors


Casanova, A More by this author
Moorman, AV More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
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Journal:
British journal of haematology
Volume:
148
Issue:
3
Pages:
394-401
Publication date:
2010-02-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:634a9de0-8900-4145-9c23-29f85bfdbba6
Source identifiers:
95979
Local pid:
pubs:95979

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