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Gating at both ends and breathing in the middle: conformational dynamics of TolC.

Abstract:

Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore through the periplasmic space and the outer membrane. Molecular dynamics simulations of TolC have been performed, and are compared to simulations of Y362F/R367S mutant, and to simulations of its hom...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1529/biophysj.108.136028

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biophysical journal Journal website
Volume:
95
Issue:
12
Pages:
5681-5691
Publication date:
2008-12-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
100784

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