Journal article
Gating at both ends and breathing in the middle: conformational dynamics of TolC.
- Abstract:
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Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore through the periplasmic space and the outer membrane. Molecular dynamics simulations of TolC have been performed, and are compared to simulations of Y362F/R367S mutant, and to simulations of its hom...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1529/biophysj.108.136028
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biophysical journal Journal website
- Volume:
- 95
- Issue:
- 12
- Pages:
- 5681-5691
- Publication date:
- 2008-12-01
- DOI:
- EISSN:
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1542-0086
- ISSN:
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0006-3495
- Source identifiers:
-
100784
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:100784
- UUID:
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uuid:63489fa9-2192-475c-bbdb-3e285f75cc84
- Local pid:
- pubs:100784
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Biophysical Society
- Copyright date:
- 2008
- Notes:
- Copyright 2008 the Biophysical Society. Published by Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/ (accessed 24/02/2014).
- Licence:
- Other
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