Journal article
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation
- Abstract:
-
Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which provide functional redundancy. Bacterial multicopy plasmids provide a paradigmatic...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
MacLean, R
Grant:
Senior Research Fellowship (WT106918AIA
+ Royal Society
More from this funder
Funding agency for:
MacLean, R
Grant:
Senior Research Fellowship (WT106918AIA
+ Instituto de Salud Carlos III
More from this funder
Grant:
PlanEstataldeI+D+i2013-2016):grants
CP15-00012,PI16-00860,
CIBER(CB06/02/0053
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Ecology and Evolution Journal website
- Volume:
- 2
- Pages:
- 873–881
- Publication date:
- 2018-04-09
- Acceptance date:
- 2018-02-15
- DOI:
- ISSN:
-
2397-334X
Item Description
- Pubs id:
-
pubs:826723
- UUID:
-
uuid:6347caed-831b-4cc3-ab43-73785d2a61af
- Local pid:
- pubs:826723
- Source identifiers:
-
826723
- Deposit date:
- 2018-02-26
Terms of use
- Copyright holder:
- Rodriguez-Beltran et al
- Copyright date:
- 2018
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41559-018-0529-z
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