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Determinants of in vitro drug susceptibility testing of Plasmodium vivax.

Abstract:

In Papua, Indonesia, the antimalarial susceptibility of Plasmodium vivax (n = 216) and P. falciparum (n = 277) was assessed using a modified schizont maturation assay for chloroquine, amodiaquine, artesunate, lumefantrine, mefloquine, and piperaquine. The most effective antimalarial against P. vivax and P. falciparum was artesunate, with geometric mean 50% inhibitory concentrations (IC50s) (95% confidence intervals [CI]) of 1.31 nM (1.07 to 1.59) and 0.64 nM (0.53 to 0.79), respectively. In c...

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Publication status:
Published

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Publisher copy:
10.1128/aac.01334-07

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
52
Issue:
3
Pages:
1040-1045
Publication date:
2008-03-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
pubs:61503
UUID:
uuid:6347bc22-91a2-48a1-9536-07485301346d
Local pid:
pubs:61503
Source identifiers:
61503
Deposit date:
2012-12-19

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