Determinants of in vitro drug susceptibility testing of Plasmodium vivax.

Journal article

In Papua, Indonesia, the antimalarial susceptibility of Plasmodium vivax (n = 216) and P. falciparum (n = 277) was assessed using a modified schizont maturation assay for chloroquine, amodiaquine, artesunate, lumefantrine, mefloquine, and piperaquine. The most effective antimalarial against P. vivax and P. falciparum was artesunate, with geometric mean 50% inhibitory concentrations (IC50s) (95% confidence intervals [CI]) of 1.31 nM (1.07 to 1.59) and 0.64 nM (0.53 to 0.79), respectively. In c...

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Authors: Russell, B; Chalfein, F; Prasetyorini, B; Kenangalem, E; Piera, K

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 52
• Issue: 3
• Pages: 1040-1045
• Publication date: 2008-03-01
• DOI: 10.1128/aac.01334-07
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Life Cycle Stages; Plasmodium falciparum; Parasitic Sensitivity Tests; Animals; Time Factors; Schizonts; Antimalarials; Inhibitory Concentration 50; Plasmodium vivax; Humans; Chloroquine