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Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study.

Abstract:

Steep action potential duration (APD) restitution has been shown to facilitate wavebreak and ventricular fibrillation. The global APD restitution properties in cardiac patients are unknown. We report a combined clinical electrophysiology and computer modelling study to: (1) determine global APD restitution properties in cardiac patients; and (2) examine the interaction of the observed APD restitution with known arrhythmia mechanisms. In 14 patients aged 52-85 years undergoing routine cardiac ...

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Publication status:
Published

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Journal:
Experimental physiology
Volume:
91
Issue:
2
Pages:
339-354
Publication date:
2006-03-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:6347527a-020e-45ac-9efa-346a6c4720e2
Source identifiers:
106321
Local pid:
pubs:106321

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