The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

Bingham, S; Beswick, PJ; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Summerfield, SG; Stevens, A; Stratton, SC; Wiseman, J

Abstract:

The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been implicated in chronic pain states in rat and man. A number of COX-2 inhibitors, including celecoxib and rofecoxib, are already used in man for the treatment of inflammatory pain. Preclinically, the dual-acting COX-2 inhibitor, GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine, where X denotes the free base], is as effective as rofecox...

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APA Style

Bingham, S., Beswick, P. J., Bountra, C., Brown, T., Campbell, I. B., Chessell, I. P., Clayton, N., Collins, S. D., Davey, P. T., Goodland, H., Gray, N., Haslam, C., Hatcher, J. P., Hunter, A. J., Lucas, F., Murkitt, G., Naylor, A., Pickup, E., Sargent, B., … Wiseman, J. (2005). The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. The Journal of Pharmacology and Experimental Therapeutics, 312(3), 1161–1169.

MLA Style

Bingham, S., et al. “The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(Methylsulfonyl)Phenyl]-Pyrazolo[1,5-b]Pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization.” The Journal of Pharmacology and Experimental Therapeutics, vol. 312, no. 3, The Journal of pharmacology and experimental therapeutics, 2005, pp. 1161–69.

Chicago Style

Bingham, S, PJ Beswick, C Bountra, T Brown, IB Campbell, IP Chessell, N Clayton, et al. 2005. “The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(Methylsulfonyl)Phenyl]-Pyrazolo[1,5-b]Pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization.” The Journal of Pharmacology and Experimental Therapeutics 312 (3): 1161–69.
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