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The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

Abstract:

The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been implicated in chronic pain states in rat and man. A number of COX-2 inhibitors, including celecoxib and rofecoxib, are already used in man for the treatment of inflammatory pain. Preclinically, the dual-acting COX-2 inhibitor, GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine, where X denotes the free base], is as effective as rofecox...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.104.075267

Authors


Bingham, S More by this author
Beswick, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Campbell, IB More by this author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
312
Issue:
3
Pages:
1161-1169
Publication date:
2005-03-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:6344aff1-8fc3-4b76-9cf8-8cb5dd103515
Source identifiers:
32923
Local pid:
pubs:32923

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