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Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

Abstract:

There is increasing evidence that hypoxia-regulated gene expression influences tumor aggressiveness, contributing to the poorer outcome of patients with hypoxic tumors. The role of the transcriptional complex hypoxia-inducible factor-1 as an important mediator of hypoxia-regulated gene expression is one of the best documented pathways. Recently, it has emerged that certain tumor-associated carbonic anhydrases (CAs) can be added to the list of known hypoxia-inducible factor-responsive genes. H...

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Publication status:
Published

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Authors


Loncaster, JA More by this author
Harris, AL More by this author
Davidson, SE More by this author
Hunter, RD More by this author
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Journal:
Cancer research
Volume:
61
Issue:
17
Pages:
6394-6399
Publication date:
2001-09-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:6341cb55-fe26-49f5-9594-9b0564b525ec
Source identifiers:
74281
Local pid:
pubs:74281

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