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Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

Abstract:

Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis.We first did a fixed-effects meta-analysis of the observational association of plasma urate and risk of coronary heart disease. We then used a conventiona...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2213-8587(15)00386-1

Authors


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Wellcome Trust More from this funder
British Heart Foundation More from this funder
NHLBI NIH HHS More from this funder
NIA NIH HHS More from this funder
Economic and Social Research Council More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Diabetes and Endocrinology Journal website
Volume:
4
Issue:
4
Pages:
327-336
Publication date:
2016-04-01
DOI:
ISSN:
2213-8587 and 2213-8595
Pmid:
26781229
Language:
English
Keywords:
Pubs id:
pubs:597834
UUID:
uuid:63401509-fd0f-4dd4-adbd-a15ed613b813
Local pid:
pubs:597834
Deposit date:
2016-11-03

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