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The effect of lowering LDL cholesterol on vascular access patency: post hoc analysis of the Study of Heart and Renal Protection.

Abstract:

BACKGROUND AND OBJECTIVES: Reducing LDL cholesterol (LDL-C) with statin-based therapy reduces the risk of major atherosclerotic events among patients with CKD, including dialysis patients, but the effect of lowering LDL-C on vascular access patency is unclear. DESIGN, SETTING, PARTICIPANTS, and MEASUREMENTS: The Study of Heart and Renal Protection (SHARP) randomized patients with CKD to 20 mg simvastatin plus 10 mg ezetimibe daily versus matching placebo. This study aimed to explore the effec...

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Publication status:
Published

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Publisher copy:
10.2215/cjn.10371013

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Role:
Author
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Journal:
Clinical journal of the American Society of Nephrology : CJASN
Volume:
9
Issue:
5
Pages:
914-919
Publication date:
2014-05-05
DOI:
EISSN:
1555-905X
ISSN:
1555-9041
URN:
uuid:633d6d1e-1426-45df-aa86-2647e2c9af9a
Source identifiers:
457673
Local pid:
pubs:457673
Language:
English
Keywords:

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