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G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

Abstract:

OBJECTIVE: Genetic and environmental factors modulate the susceptibility to diabetic nephropathy, as initiating and/or progression factors. The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic studies for 127 candidate genes for nephropathy. RESEARCH DESIGN AND METHODS: Polymorphisms were identified through sequencing of promoter, exon, and flanking intron gene ...

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Publication status:
Published

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Publisher copy:
10.2337/db08-0073

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Journal:
Diabetes
Volume:
57
Issue:
10
Pages:
2843-2850
Publication date:
2008-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:6336024e-ff24-43f3-b31b-20023625fe12
Source identifiers:
29601
Local pid:
pubs:29601

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