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Journal article

Ca2+-mobility in the sarcoplasmic reticulum of ventricular myocytes is low.

Abstract:

The sarcoplasmic reticulum (SR) in ventricular myocytes contains releasable Ca(2+) for activating cellular contraction. Recent measurements of intra-SR (luminal) Ca(2+) suggest a high diffusive Ca(2+)-mobility constant (D(CaSR)). This could help spatially to unify SR Ca(2+)-content ([Ca(2+)](SRT)) and standardize Ca(2+)-release throughout the cell. But measurements of localized depletions of luminal Ca(2+) (Ca(2+)-blinks), associated with local Ca(2+)-release (Ca(2+)-sparks), suggest D(CaSR) ...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.108.130385

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Biophysical journal More from this journal
Volume:
95
Issue:
3
Pages:
1412-1427
Publication date:
2008-08-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Keywords:
Pubs id:
pubs:106358
UUID:
uuid:6333d7ee-3137-40b5-a321-e6360c93d69d
Local pid:
pubs:106358
Source identifiers:
106358
Deposit date:
2012-12-19

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