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Multi-stage models for the failure of complex systems, cascading disasters, and the onset of disease

Abstract:

Complex systems can fail through different routes, often progressing through a series of (rate-limiting) steps and modified by environmental exposures. The onset of disease, cancer in particular, is no different. Multi-stage models provide a simple but very general mathematical framework for studying the failure of complex systems, or equivalently, the onset of disease. They include the Armitage-Doll multi-stage cancer model as a particular case, and have potential to provide new insights int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0216422

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit; Cancer Epidemiology Unit
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
14
Issue:
5
Pages:
Article: e0216422
Publication date:
2019-05-20
Acceptance date:
2019-04-20
DOI:
EISSN:
1932-6203
Pubs id:
pubs:995193
URN:
uri:6332e4af-168b-4a40-9979-d8c077287839
UUID:
uuid:6332e4af-168b-4a40-9979-d8c077287839
Local pid:
pubs:995193

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