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Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

Abstract:

This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The first part of this study focused on developing and validating anti-sera capable of detecting PHD proteins in rodent tissues. With these reagents, it was possible to assess the relative expression of each PH...

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Institution:
University of Oxford
Research group:
Ratcliffe Group
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Centre for Cellular and Molecular Physiology
Role:
Author

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Funding agency for:
J. Bhathiya Wijeyekoon
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:6330e4d5-0802-427b-a7b3-8895d94e02f2
Local pid:
ora:10460

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