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Journal article

Prox1 maintains muscle structure and growth in the developing heart.

Abstract:

Impaired cardiac muscle growth and aberrant myocyte arrangement underlie congenital heart disease and cardiomyopathy. We show that cardiac-specific inactivation of the murine homeobox transcription factor Prox1 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril disarray and growth-retarded hearts. Furthermore, we demonstrate that Prox1 is required for direct transcriptional regulation of the genes encoding the structural proteins alpha-actinin, N-...

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Publication status:
Published

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Publisher copy:
10.1242/dev.030007

Authors


Risebro, CA More by this author
Searles, RG More by this author
Melville, AA More by this author
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Journal:
Development (Cambridge, England)
Volume:
136
Issue:
3
Pages:
495-505
Publication date:
2009-02-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:632e934c-96ca-49af-addb-c1da3f14dd96
Source identifiers:
251939
Local pid:
pubs:251939

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