- Abstract:
-
Impaired cardiac muscle growth and aberrant myocyte arrangement underlie congenital heart disease and cardiomyopathy. We show that cardiac-specific inactivation of the murine homeobox transcription factor Prox1 results in the disruption of expression and localisation of sarcomeric proteins, gross myofibril disarray and growth-retarded hearts. Furthermore, we demonstrate that Prox1 is required for direct transcriptional regulation of the genes encoding the structural proteins alpha-actinin, N-...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/dev.030007
-
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- Journal:
- Development (Cambridge, England)
- Volume:
- 136
- Issue:
- 3
- Pages:
- 495-505
- Publication date:
- 2009-02-05
- DOI:
- EISSN:
-
1477-9129
- ISSN:
-
0950-1991
- URN:
-
uuid:632e934c-96ca-49af-addb-c1da3f14dd96
- Source identifiers:
-
251939
- Local pid:
- pubs:251939
- Copyright date:
- 2009
Journal article
Prox1 maintains muscle structure and growth in the developing heart.
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