- Abstract:
-
BACKGROUND: Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their influence on the outcome of allografts in nonimmunosuppressed mouse recipients. METHODS: We compared survival times of male CBA/Ca skin grafts in female CBA/Ca recipients expressing a transgenic anti-HY T-cell receptor on a RAG-1(+/+) (A1[M]RAG+) or ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/01.tp.0000155179.61445.78
-
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- Journal:
- Transplantation
- Volume:
- 79
- Issue:
- 6
- Pages:
- 648-654
- Publication date:
- 2005-03-05
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- URN:
-
uuid:632c8cac-d030-4aa7-8336-1a4c06031a48
- Source identifiers:
-
4924
- Local pid:
- pubs:4924
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression.
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