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Journal article

Therapeutic applications of imino sugars in lysosomal storage disorders.

Abstract:

The N-alkylated imino sugars have inhibitory activity against the first enzyme in the pathway for glucosylating sphingolipid in eukaryotic cells, ceramide-specific glucosyltransferase. A therapeutic approach termed 'substrate deprivation' or 'substrate reduction therapy' (SRT) aims to reduce biosynthetic capability in the cell to match the reduced lysosomal catalytic activity seen in lysosomal storage disorders. The use of N-alkylated imino sugars to establish this therapeutic strategy is des...

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Publication status:
Published

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Publisher copy:
10.2174/1568026033452483

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Current topics in medicinal chemistry
Volume:
3
Issue:
5
Pages:
561-574
Publication date:
2003-01-01
DOI:
EISSN:
1873-4294
ISSN:
1568-0266
Source identifiers:
100982
Language:
English
Keywords:
Pubs id:
pubs:100982
UUID:
uuid:6329bf88-3694-458b-bb72-531b81d82436
Local pid:
pubs:100982
Deposit date:
2012-12-19

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