- Abstract:
-
The N-alkylated imino sugars have inhibitory activity against the first enzyme in the pathway for glucosylating sphingolipid in eukaryotic cells, ceramide-specific glucosyltransferase. A therapeutic approach termed 'substrate deprivation' or 'substrate reduction therapy' (SRT) aims to reduce biosynthetic capability in the cell to match the reduced lysosomal catalytic activity seen in lysosomal storage disorders. The use of N-alkylated imino sugars to establish this therapeutic strategy is des...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2174/1568026033452483
-
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- Journal:
- Current topics in medicinal chemistry
- Volume:
- 3
- Issue:
- 5
- Pages:
- 561-574
- Publication date:
- 2003
- DOI:
- EISSN:
-
1873-4294
- ISSN:
-
1568-0266
- URN:
-
uuid:6329bf88-3694-458b-bb72-531b81d82436
- Source identifiers:
-
100982
- Local pid:
- pubs:100982
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Therapeutic applications of imino sugars in lysosomal storage disorders.
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