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Journal article

Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection.

Abstract:

Whether the number of concurrent clones in asymptomatic Plasmodium falciparum infections reflects the degree of host protection was investigated in children living in areas with different levels of transmission on the coast of Kenya. The number of concurrent clones was determined on the basis of polymorphism in msp2, which encodes the vaccine candidate antigen merozoite surface protein 2. In a low-transmission area, most children had monoclonal infections, and diversity did not predict a risk...

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Publication status:
Published

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Publisher copy:
10.1086/605652

Authors


Färnert, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Mwangi, TW More by this author
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Journal:
The Journal of infectious diseases
Volume:
200
Issue:
7
Pages:
1166-1175
Publication date:
2009-10-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:63287ed8-f188-4f4d-a803-ca5669407904
Source identifiers:
41346
Local pid:
pubs:41346

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