Journal article icon

Journal article

Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil

Abstract:

Background The extent and profiles of heterogeneity in cognitive functioning among participants in clinical trials of antidementia medication are unknown. We aimed to quantify and identify profiles of heterogeneity of cognition in Alzheimer’s disease. Methods Individual-level participant data were analyzed from five pivotal clinical trials of donepezil for Alzheimer’s disease (N = 2,919). Based on Alzheimer’s Disease Assessment Scale–Cognitive Subscale total scores from baseline up to week 1...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More from this funder
Name:
National Institute for Health Research
Grant:
RP-2017-08-ST2-006
Publisher:
Cambridge University Press
Journal:
European Psychiatry More from this journal
Volume:
64
Issue:
1
Article number:
e16
Publication date:
2021-02-15
Acceptance date:
2021-02-09
DOI:
ISSN:
0924-9338
Language:
English
Keywords:
Pubs id:
1160360
Local pid:
pubs:1160360
Deposit date:
2021-02-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP