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A role for silent synapses in the development of the pathway from layer 2/3 to 5 pyramidal cells in the neocortex.

Abstract:

The integration of neurons within the developing cerebral cortex is a prolonged process dependent on a combination of molecular and physiological cues. To examine the latter we used laser scanning photostimulation (LSPS) of caged glutamate in conjunction with whole-cell patch-clamp electrophysiology to probe the integration of pyramidal cells in the sensorimotor regions of the mouse neocortex. In the days immediately after postnatal day 5 (P5) the origin of the LSPS-evoked AMPA receptor (AMPA...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience More from this journal
Volume:
32
Issue:
38
Pages:
13085-13099
Publication date:
2012-09-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474

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