Journal article
Exosome-mediated delivery of siRNA in vitro and in vivo.
- Abstract:
-
The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered by inadequate tissue-specific delivery. Exosomes are promising tools for drug delivery across different biological barriers. Here we show how exosomes derived from cultured cells can be harnessed for delivery of siRNA in vitro and in vivo. This protocol first describes the generation of targeted exosomes through transfection of an expr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nprot.2012.131
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Authors
Bibliographic Details
- Journal:
- Nature protocols
- Volume:
- 7
- Issue:
- 12
- Pages:
- 2112-2126
- Publication date:
- 2012-12-05
- DOI:
- EISSN:
-
1750-2799
- ISSN:
-
1754-2189
- URN:
-
uuid:63119478-e7d5-4807-b899-6fd4586bd81a
- Source identifiers:
-
363843
- Local pid:
- pubs:363843
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2012
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