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Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.

Abstract:

The spatial and temporal regulation of the second messenger PtdIns(4,5)P2 has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of PIP5K1 (phosphatidylinositol 4-phosphate 5-kinase), A, B and C, are responsible for the regulation of the major pools of cellular PtdIns(4,5)P2. PIP5K1B is negatively regulated in response to oxidative stress although it remains unclear which pathways regulate its activity. In the present study, we have ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20130259

Authors


van den Bout, I More by this author
Halstead, JR More by this author
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Journal:
The Biochemical journal
Volume:
455
Issue:
3
Pages:
347-358
Publication date:
2013-11-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:63101beb-cfb3-40fb-a82e-497cf75cdf6f
Source identifiers:
438020
Local pid:
pubs:438020

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