Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.

van den Bout, I; Jones, DR; Shah, ZH; Halstead, JR; Keune, WJ; Mohammed, S; D'Santos, CS; Divecha, N

Abstract:

The spatial and temporal regulation of the second messenger PtdIns(4,5)P2 has been shown to be crucial for regulating numerous processes in the cytoplasm and in the nucleus. Three isoforms of PIP5K1 (phosphatidylinositol 4-phosphate 5-kinase), A, B and C, are responsible for the regulation of the major pools of cellular PtdIns(4,5)P2. PIP5K1B is negatively regulated in response to oxidative stress although it remains unclear which pathways regulate its activity. In the present study, we have ...

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APA Style

van den Bout, I., Jones, D. R., Shah, Z. H., Halstead, J. R., Keune, W. J., Mohammed, S., D'Santos, C. S., & Divecha, N. (2013). Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction. The Biochemical Journal, 455(3), 347–358.

MLA Style

van den Bout, I., et al. “Collaboration of AMPK and PKC to Induce Phosphorylation of Ser413 on PIP5K1B Resulting in Decreased Kinase Activity and Reduced PtdIns(4,5)P2 Synthesis in Response to Oxidative Stress and Energy Restriction.” The Biochemical Journal, vol. 455, no. 3, The Biochemical journal, 2013, pp. 347–58.

Chicago Style

Bout, I van den, DR Jones, ZH Shah, JR Halstead, WJ Keune, S Mohammed, CS D'Santos, and N Divecha. 2013. “Collaboration of AMPK and PKC to Induce Phosphorylation of Ser413 on PIP5K1B Resulting in Decreased Kinase Activity and Reduced PtdIns(4,5)P2 Synthesis in Response to Oxidative Stress and Energy Restriction.” The Biochemical Journal 455 (3): 347–58.
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