Journal article icon

Journal article

Stimulation of the alpha 7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

Abstract:

Surgery and critical illness often associate with cognitive decline. Surgical trauma or infection can independently lead to learning and memory impairments via similar, but not identical, cellular signaling of the innate immune system that promotes neuroinflammation. In this study we explored the putative synergism between aseptic orthopedic surgery and infection, the latter reproduced by postoperative lipopolysaccharide (LPS) administration. We observed that surgery and LPS augmented systemi...

Expand abstract

Actions


Access Document


Publisher copy:
10.2119/molmed.2014.00143

Authors


Journal:
Molecular medicine (Cambridge, Mass.) More from this journal
Publication date:
2014-10-01
DOI:
EISSN:
1528-3658
ISSN:
1076-1551
Language:
English
Pubs id:
pubs:488985
UUID:
uuid:630dc873-5e87-4e32-8355-cc7067a51e67
Local pid:
pubs:488985
Source identifiers:
488985
Deposit date:
2014-11-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP