Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

Journal article

OBJECTIVE: To identify new genetic associations with juvenile and adult dermatomyositis (DM). METHODS: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM....

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Authors: Miller, F; Cooper, R; Vencovský, J; Rider, L; Danko, K

• Journal: Arthritis and rheumatism
• Volume: 65
• Issue: 12
• Pages: 3239-3247
• Publication date: 2013-12-01
• DOI: 10.1002/art.38137
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Case-Control Studies; Genotype; Myositis Genetics Consortium; Middle Aged; Adolescent; Aged; Humans; Adult; Genetic Predisposition to Disease; Male; Female; European Continental Ancestry Group; Polymorphism, Single Nucleotide; Dermatomyositis; Autoimmune Diseases; Genome-Wide Association Study