Gene set analysis of lung samples provides insight into pathogenesis of progressive, fibrotic pulmonary sarcoidosis.

Journal article

RATIONALE: Approximately 60 to 70% of patients with pulmonary sarcoidosis have disease that resolves spontaneously; the rest follow a chronic course with varying levels of fibrosis. It is unclear why some patients progress and if treatment affects outcome. OBJECTIVES: To determine differential gene expression profile in lungs of patients with self-limiting sarcoidosis compared to those with progressive-fibrotic disease, and to analyze the biological relevance of these differentially expressed...

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Authors: Lockstone, H; Sanderson, S; Kulakova, N; Baban, D; Leonard, A

• Publication status: Published
• Journal: American journal of respiratory and critical care medicine
• Volume: 181
• Issue: 12
• Pages: 1367-1375
• Publication date: 2010-06-01
• DOI: 10.1164/rccm.200912-1855oc
• EISSN: 1535-4970
• ISSN: 1073-449X
• Language: English
• Keywords: Fibroblasts; Reverse Transcriptase Polymerase Chain Reaction; Biopsy; Lung; Gene Expression Profiling; Aged; Humans; Bronchi; Adult; Female; Middle Aged; Sarcoidosis, Pulmonary; Up-Regulation; Disease Progression; Male; Gene Expression