Journal article icon

Journal article

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Abstract:

Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ve young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2-negative cells in a paracrine manner. Here, we uncover the mecha...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-017-01992-5

Authors


Gonzalez-Meljem, JM More by this author
Carreno, G More by this author
Expand authors...
More from this funder
Grant:
MR/M000125/1; MR/L016729/1
National Institute for Health Research More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
1819
Publication date:
2017-11-28
Acceptance date:
2017-10-31
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:796228
URN:
uri:6301bd8f-0cb3-4b91-86a5-33b309342569
UUID:
uuid:6301bd8f-0cb3-4b91-86a5-33b309342569
Local pid:
pubs:796228

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP