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Journal article

The IGF receptor as anticancer treatment target.

Abstract:

The type 1 insulin-like growth factor receptor (IGF-1R) is overexpressed by many tumours and mediates proliferation, motility and apoptosis protection. Tumour growth and metastasis can be blocked by agents that inhibit IGF-1R expression or function, suggesting the IGF-1R as a promising treatment target. We showed that antisense-IGF-1R expression in melanoma cells leads to enhanced radiosensitivity and impaired activation of ATM, required for DNA double-strand break repair. Antisense and domin...

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Journal:
Novartis Foundation symposium
Volume:
262
Pages:
235-268
Publication date:
2004-01-01
EISSN:
1935-4657
ISSN:
1528-2511
Source identifiers:
315961
Language:
English
Keywords:
Pubs id:
pubs:315961
UUID:
uuid:62ff303a-5f27-43d8-b53d-fa15440b59a2
Local pid:
pubs:315961
Deposit date:
2014-05-14

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