The IGF receptor as anticancer treatment target.
The type 1 insulin-like growth factor receptor (IGF-1R) is overexpressed by many tumours and mediates proliferation, motility and apoptosis protection. Tumour growth and metastasis can be blocked by agents that inhibit IGF-1R expression or function, suggesting the IGF-1R as a promising treatment target. We showed that antisense-IGF-1R expression in melanoma cells leads to enhanced radiosensitivity and impaired activation of ATM, required for DNA double-strand break repair. Antisense and domin...Expand abstract
- Novartis Foundation symposium
- Publication date:
- Source identifiers:
- Copyright date:
If you are the owner of this record, you can report an update to it here: Report update to this record