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Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial.

Abstract:

BACKGROUND: Despite previous randomised trials of early beta-blocker therapy in the emergency treatment of myocardial infarction (MI), uncertainty has persisted about the value of adding it to current standard interventions (eg, aspirin and fibrinolytic therapy), and the balance of potential benefits and hazards is still unclear in high-risk patients. METHODS: 45,852 patients admitted to 1250 hospitals within 24 h of suspected acute MI onset were randomly allocated metoprolol (up to 15 mg in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Collins, R More by this author
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Journal:
Lancet
Volume:
366
Issue:
9497
Pages:
1622-1632
Publication date:
2005-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:62f7eb27-9634-4e2e-8ee3-8dfc3bb077a3
Source identifiers:
33297
Local pid:
pubs:33297

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