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Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells.

Abstract:

Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves. Here we report that loss of NRP1 or NRP2 also impairs sensory neuron positioning in the mouse head, and that this defect is a consequence of inappropriate cranial neural crest cell migration. Specifically, neural crest cells move into the norm...

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Publisher copy:
10.1242/dev.015412
Journal:
Development (Cambridge, England) More from this journal
Volume:
135
Issue:
9
Pages:
1605-1613
Publication date:
2008-05-01
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Language:
English
Keywords:
Pubs id:
pubs:428935
UUID:
uuid:62f714fd-81dc-445f-b3d5-8dc3a327ad59
Local pid:
pubs:428935
Source identifiers:
428935
Deposit date:
2013-11-16

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